Buy Humanin 1mg
Mitochondrial-derived peptide for neuroprotection, metabolic health, and longevity
Buy Humanin 1mg — Humanin is a mitochondria-encoded micropeptide that provides neuroprotection against Alzheimer's pathology, improves insulin sensitivity, and extends lifespan in multiple model organisms.
- Neuroprotection against Alzheimer's amyloid-beta toxicity
- Inhibits apoptosis via Bax pathway modulation
- Improves insulin sensitivity and metabolic function
- Reduces systemic inflammation via STAT3 activation
- Correlates with longevity — higher in centenarians
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Humanin: The Mitochondria-Encoded Longevity Peptide That Protects Against Alzheimer's and Aging
Mitochondrial Origin
Encoded in mitochondrial DNA — Humanin is a member of the newly discovered class of mitochondria-derived peptides (MDPs) that function as systemic longevity hormones.
Alzheimer's Neuroprotection
Directly inhibits amyloid-beta-induced neuronal apoptosis — the exact cell death pathway that drives Alzheimer's neurodegeneration — through multiple complementary mechanisms.
Centenarian Correlation
Plasma Humanin levels are significantly higher in centenarians and their offspring versus age-matched controls — creating a compelling longevity biomarker and therapeutic rationale.
Insulin Sensitization
Activates AMPK and improves insulin signaling — addressing the metabolic dysfunction that links aging, obesity, and neurodegeneration through shared insulin resistance pathways.
The Science Behind Humanin 1mg
▸Mitochondrial-Derived Longevity Peptide
Humanin is a 21-amino-acid peptide encoded within the 16S rRNA gene of mitochondrial DNA — the first member of a newly recognized class of mitochondria-derived peptides (MDPs) with systemic hormonal functions. Discovered through expression screening for Alzheimer's-protective genes, Humanin is secreted by mitochondria and cells in response to stress, acting in an endocrine fashion to protect against apoptosis, inflammation, and metabolic dysfunction.
▸Mechanism: Multi-Pathway Cytoprotection
Humanin acts through multiple receptors including FPRL1, gp130, and the trimeric receptor CNTFR/WSX-1/gp130 complex. Through these pathways, it inhibits Bax-induced apoptosis, activates STAT3 signaling for cellular survival, promotes AMPK for metabolic efficiency, and reduces inflammatory cytokine production. In neurons, it specifically prevents amyloid-beta-induced cell death through mechanisms that intersect with the Alzheimer's disease pathology cascade.
▸Longevity and Clinical Correlations
Humanin levels correlate with longevity — centenarians and their offspring have significantly higher plasma Humanin levels than age-matched controls. In model organisms, exogenous Humanin extends lifespan and healthspan. Its insulin-sensitizing effects have been studied for metabolic syndrome and diabetes, while its neuroprotective properties continue to drive Alzheimer's disease research.
Complete Humanin 1mg Benefits
- Neuroprotection against Alzheimer's amyloid-beta toxicity
- Inhibits apoptosis via Bax pathway modulation
- Improves insulin sensitivity and metabolic function
- Reduces systemic inflammation via STAT3 activation
- Correlates with longevity — higher in centenarians
- Mitochondrial protection against oxidative stress
- Extends lifespan in multiple model organisms
Humanin 1mg Dosing Protocol
Reconstitution: Add 1mL bacteriostatic water (1,000mcg/mL).
Dosing:
• Anti-aging: 100–250mcg subcutaneous 2–3x per week
• Neuroprotection: 500mcg subcutaneous daily for 4–8 weeks
• Cycle: 4–8 weeks on, 4 weeks off
Stack: Combine with MOTS-c for comprehensive mitochondrial peptide protocol
All information on this site is for educational purposes only. Always consult with a qualified healthcare provider before use. COA documentation is available for all products.
Humanin 1mg
COA verified · Third-party tested · US domestic shipping
Buy Now View Stack ProtocolsLongevity peptides target the root causes of aging — telomere shortening, epigenetic drift, and mitochondrial decline.
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