NAD+ 500mg
Cellular Energy & Longevity Cofactor
NAD+ is the master cellular energy molecule that declines 50% by age 50 — supplementation restores sirtuin activity, DNA repair, and mitochondrial function.
- Restores NAD+ levels that decline 50% by age 50
- Activates sirtuins (SIRT1-7) — the master longevity proteins
- Powers PARP enzymes for DNA damage repair
- Restores mitochondrial Complex I function and ATP production
- Improves physical energy and exercise performance within 1-2 weeks
COA verified · US domestic shipping
NAD+: The Master Longevity Molecule That Powers Every Cell in Your Body
50% Decline by 50
NAD+ levels drop approximately 50% between ages 20 and 50 — this decline drives most of the biochemical hallmarks of aging.
Sirtuin Activation
Sirtuins (SIRT1-7) are the master longevity proteins. NAD+ is their only substrate — no NAD+, no sirtuin activity.
DNA Repair Engine
PARP enzymes that repair DNA damage — the #1 cause of cancer and cellular aging — require NAD+ to function.
Energy Restoration
Powers Complex I of the mitochondrial electron transport chain — restoring the foundational energy production that declines with aging.
The Science Behind NAD+ 500mg
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every living cell and essential for over 500 enzymatic reactions. It is most critical for mitochondrial energy production (ATP synthesis) and as a substrate for sirtuins — the longevity proteins that control epigenetic aging.
▸The Decline Problem
NAD+ levels decline approximately 50% between age 20 and 50. This decline is directly associated with: reduced energy production, impaired DNA damage repair, epigenetic dysfunction, metabolic slowdown, and reduced stress resistance. Virtually every hallmark of aging is connected to NAD+ decline.
▸How NAD+ Works
NAD+ is required by:
→**PARP enzymes**: DNA damage repair — critical for genomic stability
→**Sirtuins (SIRT1-7)**: Epigenetic regulators that control aging, inflammation, and metabolism
→**Complex I of the electron transport chain**: Core of mitochondrial energy production
Restoring NAD+ activates all of these pathways simultaneously — a true systems-level anti-aging intervention.
▸Results
Users report significant increases in physical energy within 1-2 weeks. Exercise performance improves. Cognitive clarity and motivation improve (NAD+ drives dopamine synthesis pathways). Long-term benefits include improved metabolic markers and reduced inflammation.
Complete NAD+ 500mg Benefits
- Restores NAD+ levels that decline 50% by age 50
- Activates sirtuins (SIRT1-7) — the master longevity proteins
- Powers PARP enzymes for DNA damage repair
- Restores mitochondrial Complex I function and ATP production
- Improves physical energy and exercise performance within 1-2 weeks
- Enhances cognitive clarity, motivation, and focus
- Reduces inflammatory markers via sirtuin activation
- Synergizes with caloric restriction and exercise for longevity
NAD+ 500mg Dosing Protocol
Oral Protocol (Capsule):
• Dose: 500mg daily
• Timing: Morning with food
• Cycle: Daily ongoing — safe for extended use
Injection Protocol (Higher Bioavailability):
• Dose: 100-500mg subcutaneous or IV
• Frequency: Daily to 3x weekly
Stack with: Epithalon + GHK-Cu for comprehensive anti-aging protocol.
All information on this site is for educational purposes only. Always consult with a qualified healthcare provider before use. COA documentation is available from Apollo Peptide Sciences for all products.
Get NAD+ 500mg
Apollo Peptide Sciences — COA verified, US domestic, fast shipping.
Shop View Stack ProtocolsLongevity peptides target the root causes of aging — telomere shortening, epigenetic drift, and mitochondrial decline.
All Anti-Aging PeptidesStack NAD+ 500mg With
Anti-AgingGHK-Cu
Copper Peptide That Resets Your Genes
GHK-Cu (Copper Peptide) reverses the gene expression of 31% of aged genes, rebuilds collagen, and activates cellular cleanup — the master anti-aging signal.
Anti-AgingEpithalon
Telomere Extension & Longevity Master
Epithalon is the only known compound to stimulate telomerase and lengthen telomeres — with a 28% mortality reduction shown in a 12-year human clinical trial.
Anti-AgingNAD+ 500mg
Cellular Energy & Longevity Cofactor
NAD+ is the master cellular energy molecule that declines 50% by age 50 — supplementation restores sirtuin activity, DNA repair, and mitochondrial function.