Buy AICAR 50mg
AMPK activator for endurance enhancement, fat oxidation, and metabolic health
Trusted AICAR 50mg — AICAR (AICA ribonucleotide) is an AMPK activator that increases endurance capacity, enhances fat oxidation, and produces metabolic adaptations mimicking aerobic exercise training.
- Activates AMPK to produce exercise-mimetic metabolic effects
- Doubles endurance capacity in sedentary animal models
- Increases fatty acid oxidation via CPT1 upregulation
- Promotes mitochondrial biogenesis through PGC-1α
- Improves insulin sensitivity and glucose metabolism
COA verified · US domestic shipping
AICAR: The AMPK-Activating Exercise Mimetic That Doubled Endurance Without Training
Doubled Endurance in Studies
Salk Institute research showed AICAR administration doubled running endurance in untrained mice — producing the cardiovascular adaptation of months of training in weeks of injection.
AMPK Master Switch
AICAR directly activates AMPK — the cellular sensor that coordinates all metabolic adaptations to exercise — producing trained-state metabolism without proportional training stress.
Mitochondrial Biogenesis
Upregulates PGC-1α, the master regulator of mitochondrial creation — increasing the number of mitochondria per cell and fundamentally improving cellular energy capacity.
Fat Oxidation Enhancement
Increases CPT1 expression to transport fatty acids into mitochondria for oxidation — shifting the body's fuel preference toward fat and sparing glycogen for high-intensity efforts.
The Science Behind AICAR 50mg
▸The Exercise Mimetic AMPK Activator
AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) is a cell-permeable adenosine monophosphate analog that activates AMP-activated protein kinase (AMPK) — the master metabolic switch that senses cellular energy status and coordinates responses to energy stress. AICAR was famously used in the Salk Institute research that showed it could double the running endurance of sedentary mice, even without training — earning it the label of an "exercise pill."
▸Mechanism: AMPK and Metabolic Reprogramming
AICAR activates AMPK by mimicking the high AMP:ATP ratio that occurs during intense exercise. AMPK activation triggers a cascade that upregulates glucose uptake (GLUT4 translocation), increases fatty acid oxidation (CPT1 upregulation), promotes mitochondrial biogenesis (PGC-1α activation), and enhances insulin sensitivity — essentially programming the cellular metabolic state of a trained endurance athlete.
▸Performance and Body Composition Applications
Athletes use AICAR for endurance enhancement, accelerated metabolic adaptation during training camps, and fat oxidation in cutting phases. Its ability to increase mitochondrial content and fatty acid oxidation capacity makes it valuable for anyone seeking to improve their metabolic fitness — whether for athletic performance or long-term metabolic health and body composition.
Complete AICAR 50mg Benefits
- Activates AMPK to produce exercise-mimetic metabolic effects
- Doubles endurance capacity in sedentary animal models
- Increases fatty acid oxidation via CPT1 upregulation
- Promotes mitochondrial biogenesis through PGC-1α
- Improves insulin sensitivity and glucose metabolism
- Enhances glycogen sparing for endurance performance
- Metabolic adaptation without requiring increased training volume
AICAR 50mg Dosing Protocol
Reconstitution: Add 1–2mL bacteriostatic water.
Dosing:
• Performance: 500mcg–1mg/kg subcutaneous 1–2 hours before activity
• Metabolic/body composition: 10–20mg subcutaneous daily
• Cycle: 4–8 weeks; WADA-prohibited in competition
Note: AICAR is a prohibited substance in competitive sport
All information on this site is for educational purposes only. Always consult with a qualified healthcare provider before use. COA documentation is available for all products.
AICAR 50mg
COA verified · Third-party tested · US domestic shipping
Buy Now View Stack ProtocolsBody composition peptides optimize the GH/IGF-1 axis and metabolic signaling for simultaneous fat loss and muscle gain.
All Body Composition PeptidesStacks Best With
Stack AICAR 50mg With
HealingNAD+ 100mg
Injectable NAD+ for cellular energy, DNA repair, and anti-aging restoration
Verified NAD+ 100mg — Injectable NAD+ 100mg — the coenzyme central to cellular energy metabolism, sirtuin activation, DNA repair, and mitochondrial biogenesis for comprehensive anti-aging support.
Anti-AgingMOTS-c 5mg
Mitochondrial micropeptide for metabolic regulation, exercise adaptation, and longevity
MOTS-c 5mg For Sale — MOTS-c is a mitochondria-encoded peptide that mimics the metabolic effects of exercise, improves insulin sensitivity, reduces obesity, and activates AMPK for longevity signaling.
Body CompositionBAM-15 30mg/mL 30mL
Mitochondrial uncoupler for metabolic rate enhancement and thermogenic fat loss
Verified BAM-15 30mg/mL 30mL — BAM-15 is a mitochondria-targeted protonophore that increases metabolic rate and thermogenic fat burning without raising body temperature or causing cardiovascular toxicity.